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PHYSIOLOGY AND PATHOPHYSIOLOGY OF PULMONARY CIRCULATION AND RIGHT HEART
Evolution of the Pulmonary Circulation and the Right Heart
John B. West
Pulmonary Vascular Function
Robert Naeije
Gas Exchange
J.M.B. Hughes
Right Ventricular Function
Ryan J. Tedford
Heart-Lung Interactions
Xavier Repessé, Cyril Charron, and Antoine Vieillard-Baron
PATHOBIOLOGY OF PULMONARY VASCULAR DISEASE AND RIGHT VENTRICULAR FAILURE
Pathology of Pulmonary Vascular Diseases
Peter Dorfmüller
Pathobiology of Pulmonary Hypertension
Mark L. Ormiston and Nicholas W. Morrell
Pathobiology of Right Ventricular Failure
Anna R. Hemnes and Evan L. Brittain
CLINICAL ASSESSMENT OF PULMONARY HYPERTENSION
Clinical Features
Andrew J. Peacock and A. Colin Church
Echocardiography
Lawrence Rudski and Jonathan Afilalo
Imaging and Pulmonary Hypertension: Chest Radiography, Ventilation-Perfusion Scintigraphy, and Computed Tomography
Michael Sproule
Imaging: Emerging Modalities (Magnetic Resonance and Nuclear Imaging)
A. Vonk Noordegraaf and O.A. Spruijt
Exercise Testing in Pulmonary Hypertension
Daniel Dumitrescu and Ronald J. Oudiz
Clinical Assessment of PH: Biomarkers
Adam Torbicki, Anna Fijałkowska, and Marcin Kurzyna
Cardiac Catheterization
Gabor Kovacs and Horst Olschewski
Classification of Pulmonary Hypertension
Lewis J. Rubin
GROUP 1: PULMONARY ARTERIAL HYPERTENSION
Idiopathic Pulmonary Arterial Hypertension
Lewis J. Rubin
Heritable Pulmonary Hypertension
James E. Loyd, John H. Newman, and Eric D. Austin
Pulmonary Arterial Hypertension Associated with Drugs and Toxins
Olivier Sitbon, Caroline O’Connell, Laurent Savale, David Montani, Marc Humbert, and Gerald Simonneau
Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases
Todd M. Kolb and Paul M. Hassoun
Portopulmonary Hypertension
Rodrigo Cartin-Ceba and Michael J. Krowka
Pulmonary Arterial Hypertension Associated with HIV Infection
Rudolf Speich
Pulmonary Hypertension Related to Congenital Systemic-to-Pulmonary Shunts
Michele D’Alto and Konstantinos Dimopoulos
Schistosomiasis
Francisca Gavilanes, Caio Julio Cesar Fernandes, Carlos Jardim, and Rogerio Souza
Pulmonary Hypertension in Pregnancy
Xavier Jaïs, Laura Claire Price, David Montani, Laurent Savale, Olivier Sitbon, Gérald Simonneau, Karen M. Olsson, and Marc Humbert
Pulmonary Venoocclusive Disease and Pulmonary Capillary Hemangiomatosis
Lewis J. Rubin
Pulmonary Arterial Hypertension Registries
Edmund M.T. Lau and Marc Humbert
DRUG AND NONDRUG TREATMENT OF GROUP 1 PULMONARY ARTERIAL HYPERTENSION
Conventional Medical Therapies: Supportive Therapies and General Clinical Care Measures
Mardi Gomberg-Maitland
Calcium Channel Blockers in the Treatment of Pulmonary Arterial Hypertension
Jonathan D. Rich and Stuart Rich
Prostacyclins
Vallerie V. McLaughlin and Harold I. Palevsky
Endothelin Receptor Antagonists
Daniel Fox, Steven Pugliese, Jeffrey Robinson, Brian Graham, Edward C. Dempsey, Todd M. Bull, and David B. Badesch
Phosphodiesterase Type-5 Inhibitors
Mark Toshner and Joanna Pepke-Zaba
Soluble Guanylate Cyclase Stimulators and Activators
Hossein-Ardeschir Ghofrani, Manuel Jonas Richter, Jan Grimminger, Hennig Gall, Werner Seeger, and Friedrich Grimminger
Rehabilitation
Ekkehard Grünig and Nicola Benjamin
Combination Therapy for Pulmonary Arterial Hypertension
Marius M. Hoeper
Atrial Septostomy and Potts Procedure
Julio Sandoval and Jorge Gaspar
Lung Transplantation for Pulmonary Arterial Hypertension Including Bridging to Transplantation
Paul A. Corris
Future of Pulmonary Arterial Hypertension Therapy
Astrid Weiss, Tatyana Novoyatleva, Baktybek Kojonazarov, and Ralph Theo Schermuly
GROUP 2: PULMONARY HYPERTENSION ASSOCIATED WITH LEFT HEART CONDITIONS
World Health Organization Pulmonary Hypertension Group 2: Pulmonary Hypertension due to Left Heart Disease
Gregory D. Lewis
Diagnosis and Clinical Relevance of Pulmonary Hypertension Secondary to Mitral or Aortic Valve Diseases or Congenital Left-Sided Cardiac Abnormalities
Patrizio Lancellotti, Christine Selton-Suty, and Damien Voilliot
Treatment of Pulmonary Hypertension in Left Heart Disease
Marco Guazzi
GROUP 3: PULMONARY HYPERTENSION ASSOCIATED WITH HYPOXIA, HYPOVENTILATION, AND LUNG DISEASE
Chronic High-Altitude Exposure
Dante Penaloza
Hypoventilation and Sleep Apnea Syndromes
Ari Chaouat, Emmanuel Gomez, Magalie Mercy, Anne Guillaumot, and François Chabot
Chronic Obstructive Pulmonary Disease (COPD)
Joan Albert Barbera and Isabel Blanco
Interstitial Lung Disease and Pulmonary Hypertension
Steven D. Nathan
Combined Pulmonary Fibrosis and Emphysema Syndrome
Vincent Cottin
GROUP 4: CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION
Diagnosis of Chronic Thromboembolic Pulmonary Hypertension
Irene M. Lang, Daniel Dalos, and Christian Gerges
Medical Therapy for Chronic Thromboembolic Pulmonary Hypertension
Nick H. Kim
Balloon Pulmonary Angioplasty
Hiromi Matsubara and Aiko Ogawa
Pulmonary Thromboendarterectomy
Michael M. Madani
PULMONARY HYPERTENSION WITH UNCLEAR AND/OR MULTIFACTORIAL MECHANISMS
"Group 5" Pulmonary Hypertension with Unclear and/or Multifactorial Mechanisms
Andrew J. Peacock
Pulmonary Hypertension in Sickle Cell Disease and Thalassemia
Claudia R. Morris and Mark T. Gladwin
ACUTE PULMONARY EMBOLISM
Diagnosis of Acute Pulmonary Thromboembolism
Arnaud Perrier and Marc Righini
Treatment of Acute Pulmonary Embolism
Stavros V. Konstantinides
PEDIATRIC PULMONARY HYPERTENSION
Pulmonary Hypertension in Children: A Global Perspective
R.M.F. Berger
Idiopathic Pulmonary Arterial Hypertension in Children
Dunbar Ivy
Persistent Pulmonary Hypertension of the Newborn: Pathophysiology and Treatment
Erica Mandell, Steven H. Abman, and Robin H. Steinhorn
PULMONARY CIRCULATION IN CRITICAL CARE
Acute Lung Injury and Acute Respiratory Distress Syndrome
Laura Claire Price and S. John Wort
Severe Right Ventricular Failure
Rebecca Vanderpool and Marc A. Simon
PULMONARY CIRCULATION IN ENVIRONMENTAL STRESS
Exercise
André La Gerche
Pulmonary Circulation at High Altitude
Erik R. Swenson
PULMONARY ARTERIO-VENOUS MALFORMATIONS AND SHUNTS
Pulmonary Circulation After Palliative Cavopulmonary Connections
Mathieu Vergnat and Elie Fadel
The Hepatopulmonary Syndrome
Michael B. Fallon and Moises I. Nevah Rubin
Pulmonary Arteriovenous Malformations
Claire L. Shovlin
PULMONARY VASCULAR TUMORS AND PULMONARY VASCULITIS
Pulmonary Vascular Tumors
Demosthenes G. Papamatheakis and Kim M. Kerr
Pulmonary Vasculitis
Cassandra Batzlaff and Karina Keogh
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