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Author | Sami I. Said |
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Table Of Content | Part 1 Cell injury and inflammation: inflammation, cell injury and apoptosis; proinflammatory and antiinflammatory response cytokines in the inflammatory response. Part 1 Proinflammatory peptides: proinflammatory peptides in sensory nerves of the airways; sensory neuropeptides and bronchial hyperresponsiveness; the tachykinin family of peptides and their receptors; endothelins in inflammation; endothelins in the lung; proinflammatory peptides in relation to other inflammatory mediators; cellular regulation of kinin receptors - potential roles in inflammation. Part 3 Antiinflammatory peptides: modulation of inflammatory effects of cytokines by the neuropeptide -MSH; regulation of VIP gene expression; neuroregulation of pulmonary immune responses by VIP and substance P; role of vasoactive intestinal peptide in myocardial ischaemia - reperfusion injury; antiinflammatory actions of VIP in the lungs and airways; VIP regulation of neuronal proliferation and differentiation; implications for neuronal repair; neurotrophic action of VIP - from CNS ontogeny to therapeutic strategy. Part 4 Modulation of peptide action - therapeutic applications: long-acting VIP analogs; catalytic anti-VIP antibodies and their relevance to the airways; enzymatic degradation of bradykinin; enzymatic modulation of the tachykinins and VIP in the lung; therapeutic effects and immunomodulatory activities of natriuretic peptides. |
Publish Date | 20 Jan 1998 |